Francisco de Asís Cabrero: Vuelta al mundo en busca de la historia

Francisco de Asís Cabrero Torres-Quevedo (Santander 1912-Madrid 2005) completó su trayectoria profesional con la realización de un gran número de viajes internacionales. Estos itinerarios encerraban el propósito declarado de recopilar datos y experiencias para la realización de “el libro”, como él mismo lo llamaba, de historia de la arquitectura. Cabrero documentó sus andaduras por los cinco continentes mediante un importante número de fotografías. Estas fotografías, o más bien sus negativos, constituyen el grueso de la donación realizada en 2014 por la familia Cabrero al Archivo General de la Universidad de Navarra. En los viajes, que de por sí tienen un gran atractivo, se aprecia una maduración teórico-histórica en la mentalidad del propio Cabrero. En lo que respecta a la fotografía, despunta el hecho de que trascendiera al cuaderno de viaje y superara tradicional boceto arquitectónico como instrumento de representación principal para la toma de apuntes. Francisco Cabrero es modelo de arquitecto moderno que utiliza la imagen fotográfica como herramienta documental del viaje.Francisco de Asís Cabrero Torres-Quevedo (1912-2005) completed his career travelling around the world. These itineraries were proposed to collect data and experiences for the realization of “the book” –as he called it–, a history of architecture. Cabrero documented his adventures across the five continents through a large number of photographs. These pictures, or rather negatives, constitute the donation made in 2014 by the Cabrero family to the General Archive of the University of Navarra. On trips, which themselves are very interesting, we can see a theoretical and historical maturation in Cabrero own mentality. On photography, blunts the fact that overcome traditional architectural sketch as his primary representation and note taking. Francisco Cabrero is a model of modern architect who uses the photographic image as a documentary travelling tool

Validation and Search of the Ideal Cut-Off of the Sysmex UF-1000i (R) Flow Cytometer for the Diagnosis of Urinary Tract Infection in a Tertiary Hospital in Spain

Urinary tract infections (UTI) are one of the most prevalent infections. A rapid and reliable screening method is useful to screen out negative samples. The objective of this study was to validate the Sysmex flow cytometer UF-1000i by evaluating its accuracy, linearity and carry-over; and define an optimal cut-off value to be used in routine practice in our hospital. For the validation of the UF-1000i cytometer, precision, linearity and carry-over were studied in samples with different counts of bacteria, leukocytes and erythrocytes. Between March and June 2016, urine samples were tested in the Clinical Microbiology Laboratory at University Miguel Servet Hospital, in Spain. Samples were analyzed with the Sysmex UF-1000i cytometer, and cultured. Growth of >= 10(5) CFUs/mL was considered positive. The validation study reveals that the precision in all the variables is acceptable; that there is a good linearity in the dilutions performed, obtaining values almost identical to those theoretically expected; and for the carry-over has practically null values. A total of 1, 220 urine specimens were included, of which 213 (17.4%) were culture positive. The optimal cut-off point of the bacteria-leukocyte combination was 138.8 bacteria or 119.8 leukocytes with an S and E of 95.3 and 70.4%, respectively. The UF-1000i cytometer is a valuable method to screen urine samples to effectively rule out UTI and, may contribute to the reduction of unnecessary urine cultures

Genomic Population Structure of the Main Historical Genetic Lines of Spanish Merino Sheep

According to historiographical documentation, the Romans first began to select Merino sheep in the Iberian Peninsula during the first century, with the aim of obtaining a breed appreciated for the quality of its wool. This process continued locally during the Middle Ages, when Spanish sheep were protected, and their export to foreign countries was banned. It was during the 16th century when individual Merino sheep were allowed to spread around the world to be used to improve the wool quality of local breeds. However, the wool crisis of the 1960s shifted the selection criteria of the Merino breed towards meat production at the expenses of wool. Consequently, individuals that display the genetic and phenotypic characteristics of those sheep originally bred in the kingdom of Spain in the Middle Ages are extremely difficult to find in commercial herds. In this study, we characterized the genetic basis of 403 individuals from the main historical Spanish Merino genetic lines (Granda, Hidalgo, Lopez-Montenegro, Maeso, Donoso and Egea), which were bred in isolation over the last 200 years, using a genomic approach based on genotyping data from the Axiom™ Ovine 50 K SNP Genotyping Array. Our analysis included measuring population structure, genomic differentiation indexes, runs of homozygosity (ROH) patterns, and an analysis of molecular variance (AMOVA). The results showed large genetic differences between the historical lines, even though they belong to the same breed. In addition, ROH analysis showed differences due to increased inbreeding among the ancient generations compared with the modern Merino lines, confirming the breed’s ancestral and closed origin. However, our results also showed a high variability and richness within the Spanish historical Merino lines from a genetic viewpoint. This fact, together with their great ability to produce high-quality wool, suggests that ancestral Merino lines from Spain should be considered a valuable genetic population to be maintained as a resource for the improvement of wool-producing sheep breeds all around the world

Efecto del destete sobre el perfil de ácidos grasos de corderos de raza merina

Con la finalidad de estudiar el efecto de la prolongación del aporte de leche materna a los corderos de la raza Merina Española sobre las características de la grasa intramuscular y subcutánea, se han empleado 16 corderos machos de raza Merina Española distribuidos en dos lotes: corderos no destetados y que han permanecido con la madre hasta el día de su sacrificio y corderos destetados con 12 kg de peso vivo y que desde ese momento han ingerido únicamente alimento concentrado. El perfil lipídico de la grasa intramuscular y subcutánea se determinó por cromatografía gaseosa. Los corderos que fueron destetados con 12 kg de peso vivo y que fueron alimentados con alimento concentrado hasta el día de su sacrificio presentaron mejor conformación que los corderos que fueron alimentados con leche materna y alimento concentrado hasta el día de su sacrificio. Los corderos que recibieron leche materna hasta el día de su sacrificio presentaron mayor contenido de ácidos grasos deseables para la salud humana (9cis-11trans CLA y serie n-3)

Carcass and meat quality in light lambs in the segureña breed

Meat and carcass quality were studied in 124 Segureña breed lambs, 62 males and 62 females, slaughtered at the market weight, of 19-25 kg. Carcasses, with a yield between 48 percent (CCW/SW) and 55 percent (HCW/EW), were qualified for the most part in the 2 class of conformation as a fairly fatty, of 2/3 covered kidney and pink color muscle. There were differences among sexes for the fatness scores. The pelvic limb represents the 33.6 percent of the carcass, the shoulder 19.5 percent, the ribs+loin 17.7 percent, the breast 11.1 percent, the neck 7.3 percent, and the anterior ribs 6.7 percent; for commercial categories 58.1 percent pertained to the first category, 19.5 percent to the second and 19.8 percent to the third. Carcass were formed by 19.9 percent of fat, 52.7 percent muscle and 19.2 percent bone; these values show an ideal degree of fatness, in the local market. The sex had a significant effect on the percentage of fat and bone of the carcass. The average pH values, 6.6 and 6.5, following the preparation of the carcass for m. longissimus dorsi and m. triceps, decreased to 5.8 and 5.9, respectively, at 24 hours post mortem. These muscles presented a water holding capacity of 16.4 and 9.9 percent, and a tenderness of 3866 and 3945 g/cm2. The haem pigments and the color of m. longissimus dorsi and m. rectus abdominis confirm the results of its subjective evaluation.Se estudiaron características de calidad de la canal y de la carne en 124 corderos, 62 machos y 62 hembras, de raza Segureña sacrificados a peso de mercado, 19-25 kg. Las canales, con rendimientos entre el 48 p.100 (PCF/PVS) y el 55 p.100 (PCC/PVV), son de conformación normal (nota 2), medianamente grasas, de riñón cubierto 2/3 y músculo de color rosa; registrándose diferencias entre sexos para las calificaciones de engrasamiento. Al despiece, la pierna representó el 33,6 p.100 de la canal, la espalda el 19,5 p.100, el costillar el 17,7 p.100, los bajos el 11,1 p.100, el cuello el 7,3 p.100 y el badal el 6,7 p.100; lo que por categorías comerciales supone el 58,1 p.100 para las de 1ª, el 19,5 p.100 y 19,8 p.100 para las de 2ª y 3ª, respectivamente. La canal contenía 19,9 p.100 de grasa, 52,7 p.100 de músculo y 19,2 p.100 de hueso lo que muestra su buen grado de acabado. El sexo afectó significativamente al porcentaje de grasa y hueso de la canal. Los valores iniciales de pH, 6,6 y 6,3 para m. longissimus dorsi y m. triceps brachii, descienden a 5,8 y 5,9 a las 24 horas post mortem, respectivamente. La capacidad de retención de agua de estos músculos fue de 16,4 y 9,9 p.100 y su dureza media 3866 y 3945 g/cm2. El pigmento hemínico y el color de m. longissimus dorsi y m. rectus abdominis confirman la valoración subjetiva del color de la carne

Randomized crossover pharmacokinetic evaluation of subcutaneous versus intravenous granisetron in cancer patients treated with platinum-based chemotherapy

BACKGROUND: 5-HT3-receptor antagonists are one of the mainstays of antiemetic treatment, and they are administered either i.v. or orally. Nevertheless, sometimes neither administration route is feasible, such as in patients unable to admit oral intake managed in an outpatient setting. Our objective was to evaluate the bioavailability of s.c. granisetron. PATIENTS AND METHODS: Patients receiving platinum-based chemotherapy were randomized to receive 3 mg of granisetron either s.c. or i.v. in a crossover manner during two cycles. Blood and urine samples were collected after each cycle. Pharmacokinetic parameters observed with each administration route were compared by analysis of variance. RESULTS: From May to November 2005, 31 patients were included and 25 were evaluable. Subcutaneous granisetron resulted in a 27% higher area under the concentration-time curve for 0-12 hours (AUC(0-12h)) and higher levels at 12 hours, with similar values for AUC(0-24h). The maximum concentration was lower with the s.c. than with the i.v. route and was observed 30 minutes following s.c. administration. CONCLUSION: Granisetron administered s.c. achieves complete bioavailability. This is the first study that shows that s.c. granisetron might be a valid alternative to i.v. delivery. Further trials to confirm clinical equivalence are warranted. This new route of administration might be especially relevant for outpatient management of emesis in cancer patients

Francisco de Asís Cabrero: Vuelta al mundo en busca de la historia

Francisco de Asís Cabrero Torres-Quevedo (Santander 1912-Madrid 2005) completó su trayectoria profesional con la realización de un gran número de viajes internacionales. Estos itinerarios encerraban el propósito declarado de recopilar datos y experiencias para la realización de “el libro”, como él mismo lo llamaba, de historia de la arquitectura. Cabrero documentó sus andaduras por los cinco continentes mediante un importante número de fotografías. Estas fotografías, o más bien sus negativos, constituyen el grueso de la donación realizada en 2014 por la familia Cabrero al Archivo General de la Universidad de Navarra. En los viajes, que de por sí tienen un gran atractivo, se aprecia una maduración teórico-histórica en la mentalidad del propio Cabrero. En lo que respecta a la fotografía, despunta el hecho de que trascendiera al cuaderno de viaje y superara tradicional boceto arquitectónico como instrumento de representación principal para la toma de apuntes. Francisco Cabrero es modelo de arquitecto moderno que utiliza la imagen fotográfica como herramienta documental del viaje.Francisco de Asís Cabrero Torres-Quevedo (1912-2005) completed his career travelling around the world. These itineraries were proposed to collect data and experiences for the realization of “the book” –as he called it–, a history of architecture. Cabrero documented his adventures across the five continents through a large number of photographs. These pictures, or rather negatives, constitute the donation made in 2014 by the Cabrero family to the General Archive of the University of Navarra. On trips, which themselves are very interesting, we can see a theoretical and historical maturation in Cabrero own mentality. On photography, blunts the fact that overcome traditional architectural sketch as his primary representation and note taking. Francisco Cabrero is a model of modern architect who uses the photographic image as a documentary travelling tool